Selank: A Research Overview
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) that is an analog of the immune peptide tuftsin. It has been studied in rodent research on gene expression in immune tissue and in the brain.
Chemical identity
| Compound | Selank |
|---|---|
| Also known as | TP-7, Selanc, TKPRPGP |
| Class | Synthetic heptapeptide, an analog of tuftsin |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP) |
| Molecular formula | C33H57N11O9 |
| Molecular weight | 751.9 g/mol |
| CAS number | 129954-34-3 |
Background
Selank has the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is built from tuftsin, a four-amino-acid fragment (Thr-Lys-Pro-Arg) of the human immunoglobulin G heavy chain, extended at the C-terminus with Pro-Gly-Pro.
It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Published research includes rodent studies of gene expression in the spleen and in the brain.
Selank has not been evaluated by the U.S. FDA.
What the published literature reports
- Mouse spleen
Measured the expression of inflammation-related genes in mouse spleen at several time points after Selank and its fragments, and reported changes that varied over time.
Mol Immunol, 2014 PubMed - Rat hippocampus
Reported that intranasal Selank changed BDNF expression in the rat hippocampus.
Dokl Biol Sci, 2008 PubMed
How to read this literature
The work cited above spans mouse spleen, rat hippocampus. Findings from cell culture or animal models, and review articles that summarise them, do not establish how a compound behaves in other systems. Each citation links to the original record so you can read it directly.
Summaries describe what each cited paper reports in its own model system. They are not claims about the effects of this product.
For laboratory research use only. Not for human or veterinary use. See our Research Use Only page.